C. M. Boo, C. L. Ou-Yang, and K. Omar-Hor. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Compounds in cacti. However, the result of this study was not promising because of the low selectivity index of 0.94. The only antiparasitic investigation on P. bleo was reported by Marston et al. Description. J Ethnopharmacol 96(1–2):287–294 CrossRef PubMed Google Scholar Apart from the cytotoxic activities against cancer cell lines, crude methanol extract and its fractions (hexane, water, and ethyl acetate) did not show any cytotoxicity to the normal human fibroblast cell lines, MRC-5 . This plant has translucent rounded white to pink berries which turn to yellow or orange with the diameter of 2 cm upon ripening.  reported high tumor inhibition activity in “potato disc inhibition assay” using crown gall tumors (LC50 77 ppm). The total carotenoid content of the fruit was found to be 13.3 μg/g, making P. bleo fruit a high carotenoid food source among the wild fruits in Panama. The current review highlights the association between the traditional usage of the plant and the reported anticancer, antibacterial, and antinociceptive effects tested in different studies. A. Bak, J. H. den Breeijen, and D. E. Grobbee, “Reduction in blood pressure with a low sodium, high potassium, high magnesium salt in older subjects with mild to moderate hypertension,”, A. Marston, G. Dudan, M. P. Gupta, P. N. Solis, M. D. Correa, and K. Hostettmann, “Screening of Panamanian plants for molluscicidal activity,”, A. G. Porter and R. U. Jänicke, “Emerging roles of caspase-3 in apoptosis,”, T. Komiya, M. Kyohkon, S. Ohwaki et al., “Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells,”, M. Gerber, M. C. Boutron-Ruault, S. Hercberg, E. Riboli, A. Scalbert, and M. H. Siess, “Food and cancer: state of the art about the protective effect of fruits and vegetables,”, V. di Matteo and E. Esposito, “Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis,”, P. Knekt, R. Jarvinen, A. Reunanen, and J. Maatela, “Flavonoid intake and coronary mortality in Finland: a cohort study,”, R. A. Mustafa, A. Abdul Hamid, S. Mohamed, and F. A. Bakar, “Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants,”, E. B. Breidenstein, C. de la Fuente-Núñez, and R. E. Hancock, “Pseudomonas aeruginosa: all roads lead to resistance,”, C. Chu, C.-H. Chiu, W.-Y. Table 6 shows the reported IC50 values (μg/mL) for the antiproliferative effects of P. bleo extracts and fractions. Pharmacological evaluation of plants is based on their traditional uses. P. bleo has been shown to possess antibacterial, antiviral, and antifungal properties in vitro. It will also assist in setting appropriate policy and guidelines in the usage of herbal medicine. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. This plant is a healthy vegetable and contribute significantly to the health management of man,it is therefore recommended for daily nutritional need. No information is available in the literature. In addition, it is taken for detoxification and revitalizing the body [27, 28, 40]. Callus, cell suspension and hairy root cultures of P. bleo have been successfully induced. %PDF-1.5 i have many unique pereskia but not sure which of them (propably bleo) ? To date, no report is available on the in vivo antiproliferative activities of P. bleo. Preparing “ina kuamakalet”: the inflorescence is mixed with the excrements of red ants by using a special mortar and then moistened with water. The flowers are white, cream, or pinkish with 2.5–5 cm diameter and strongly scented. Antibacterial and antifungal effect of the extracts, E. J. Edwards and M. J. Donoghue, “Pereskia and the origin of the cactus life-form,”, E. J. Edwards, R. Nyffeler, and M. J. Donoghue, “Basal cactus phylogeny: implications of, R. M. Ogburn and E. J. Edwards, “Anatomical variation in Cactaceae and relatives: trait lability and evolutionary innovation,”. INTRODUCTION Ever since the epidemiological consequences of free radicals on certain diseases were disclosed, there is a growing interest in searching for the beneficial health effects of certain foods and plants. Basionym name is defined as “previously published legitimate name-bringing or epithet-bringing synonym from which a new name is formed for a taxon of different rank or position taxon of different rank or position” . Wu, C.-H. Chu, T.-P. Liu, and J. T. Ou, “Large drug resistance virulence plasmids of clinical isolates of, K. Hiramatsu, H. Hanaki, T. Ino, K. Yabuta, T. Oguri, and F. Tenover, “Methicillin-resistant, I. T. Matsuse, Y. The leaf of this plant has been used in Malaysian traditional medicine for the prevention and treatment of breast cancer. The new twigs may be spineless while the trunk may have up to 90 spines in areoles, each 2–6.5 cm long. R. P. Wunderlin and B. F. Hansen, “Atlas of Florida Vascular Plants,” 2008, N. P. Taylor, D. Zappi, P. Braun, and M. Machado, “. Both of the extracts demonstrated anti-HIV activity. Key words: Pereskia bleo, Cactaceae, antioxidant activity, phenolic content. Sogand Zareisedehizadeh, Chay-Hoon Tan, Hwee-Ling Koh, "A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC", Evidence-Based Complementary and Alternative Medicine, vol. Consideration was also given for summarization of the studies reported on health benefits, pharmacological activities and different food products. Unlike other members of the cactus family, this beauty is the only cactus genus that has persistent non-succulent leaves. Its fruit is consumed by some ethnic groups in Panama as a wild fruit . Its common names are Barbados gooseberry or lemon vine [12, 13] and it is native to tropical America . This review revealed the association between the traditional usage of P. bleo and reported pharmacological properties in the literature. B. Abdul, S. M. Mohan, A. S. Al-Zubairi, M. M. Elhassan, and M. Y. Ibrahim, “Biological activities of, R. T. Bárcenas, C. Yesson, and J. In contrast, Pereskia species within Clade B typically delay forming bark, thus giving the stem the potential to become a major organ for photosynthesis . However, in some studies, P. bleo did not show appreciable cytotoxic effect . Cancer is one of the main causes of mortality and morbidity. The methanol, dichloromethane, ethyl acetate, and hexane extracts of P. bleo leaves were tested [8, 25]. It has been cultivated in Malaysia for decorative and medicinal purposes .. Plant Part Used In addition, P. bleo and P. grandifolia are the only exceptions of Pereskia which grow in areas receiving considerably high annual rainfall more than 187 mm per wet month. In general, although different studies used plant materials from different sources and nonsimilar extraction methods, ethyl acetate and hexane extracts appear to be the strongest antioxidant extracts from the P. bleo leaves [8, 25, 37]. �� � w !1AQaq"2�B���� #3R�br� Both are believed to have anti-cancer, anti-tumor, anti-rheumatic, anti-ulcer, and anti-inflammatory properties. Natural Heritage Trust, “Weed Management Guide, Leaf cactus. It is usually taken raw or as a decoction of its fresh leaves. stream One solution to this problem is to supplement the diet with antioxidant compounds found in natural plant sources . 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